a Record control number 36142220

a ISSN 1083-4389

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WD300

b Item number .I58 2009

a Personal name Cam, Sebahat.

h Medium Electronic Document

a Title The Interaction Between Helicobacter pylori and Atopy: Does Inverse Association Really Exist?

c Statement of responsibility, etc Sebahat Cam, Deniz Ertem, Tunc Akkoc, Isil Barlan, Ender Pehlivanoglu.

b Name of publisher, distributor, etc Wiley-Blackwell,

c Date of publication, distribution, etc 2009.

a Summary, etc Aim: To date, cross-sectional and case–control studies suggest an inverse association between Helicobacter pylori infection and atopic diseases, whereas the immunologic basis has not been studied yet. In this study we investigated T helper (Th) cell function in H. pylori-infected children and compared cytokine responses in atopic and non-atopic groups. Methods: The study groups was recruited from a cohort of 327 healthy children evaluated and followed-up for 6 years to assess the natural history of H. pylori infection. Seventy-four of 136 healthy children who underwent 13C urea breath test were eligible and accepted to participate. All participants were evaluated by a questionnaire, and skin-prick testing. According to the results, children were divided into four groups with respect to the presence or absence of H. pylori and atopy. Peripheral blood mononuclear cells isolated from 34 of 74 children were cultured with H. pylori, Der p 1, and phytohemagglutinin (PHA). Interferon-gamma (IFN-γ), interleukin (IL)-4 and IL-10, transforming growth factor-beta (TGF-β) levels were measured in supernatants. Results: The frequency of atopy was lower in H. pylori-infected group (31.9% vs. 48.1, p = .22), while atopic symptoms were similar between infected and non-infected children. While PHA and H. pylori induced IFN-γ levels were significantly higher in H. pylori-infected children, concomitant presence of both atopy and H. pylori decreased the level of PHA and H. pylori induced IFN-γ production. PHA and Der p 1-induced IL-4 levels were higher in atopic children, and IL-4 production was suppressed when they were concomitantly infected with H. pylori. The production of TGF-β was found to be suppressed in atopic children irrespective of the presence of H. pylori infection. Conclusion: The results of the current study demonstrated a counteractive Th1 and Th2 cytokine interaction between H. pylori infection and atopy. However, this counteractive immunologic balance did not protect against atopy. [ABSTRACT FROM AUTHOR]

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Allergy

a Topical term or geographic name as entry element Helicobacter Pylori Infections

a Topical term or geographic name as entry element Helicobacter Diseases

g Relationship information FEB 2009, Vol. 14 Issue 1, p1-8. 8p. 1 Diagram, 1 Chart, 4

t Title Helicobacter

x International Standard Serial Number 10834389

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1111/j.1523-5378.2009.00660.x